Detalhe da pesquisa
1.
Evaluating drug-drug interaction risk associated with peptide analogues using advanced in vitro systems.
Drug Metab Dispos
; 2023 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38050097
2.
Challenges and Opportunities for In Vitro-In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation.
Drug Metab Dispos
; 51(12): 1591-1606, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37751998
3.
Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Disposition of Imaging Biomarker Gadoxetate in Rats.
Mol Pharm
; 18(8): 2997-3009, 2021 08 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34283621
4.
When special populations intersect with drug-drug interactions: Application of physiologically-based pharmacokinetic modeling in pregnant populations.
Biopharm Drug Dispos
; 42(4): 160-177, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-33759451
5.
Towards Further Verification of Physiologically-Based Kidney Models: Predictability of the Effects of Urine-Flow and Urine-pH on Renal Clearance.
J Pharmacol Exp Ther
; 368(2): 157-168, 2019 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-30413628
6.
Comprehensive Evaluation of the Utility of 20 Endogenous Molecules as Biomarkers of OATP1B Inhibition Compared with Rosuvastatin and Coproporphyrin I.
J Pharmacol Exp Ther
; 368(1): 125-135, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30314992
7.
Hepatic Organic Anion Transporting Polypeptide-Mediated Clearance in the Beagle Dog: Assessing In Vitro-In Vivo Relationships and Applying Cross-Species Empirical Scaling Factors to Improve Prediction of Human Clearance.
Drug Metab Dispos
; 47(3): 215-226, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-30593544
8.
Quantitative Translation of Microfluidic Transporter in Vitro Data to in Vivo Reveals Impaired Albumin-Facilitated Indoxyl Sulfate Secretion in Chronic Kidney Disease.
Mol Pharm
; 16(11): 4551-4562, 2019 11 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31525064
9.
A population pharmacokinetic model for simvastatin and its metabolites in children and adolescents.
Eur J Clin Pharmacol
; 75(9): 1227-1235, 2019 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-31172248
10.
In Vitro-In Vivo Extrapolation of OATP1B-Mediated Drug-Drug Interactions in Cynomolgus Monkey.
J Pharmacol Exp Ther
; 365(3): 688-699, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-29643253
11.
Predicting Human Clearance of Organic Anion Transporting Polypeptide Substrates Using Cynomolgus Monkey: In Vitro-In Vivo Scaling of Hepatic Uptake Clearance.
Drug Metab Dispos
; 46(7): 989-1000, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29720472
12.
Modelling of atorvastatin pharmacokinetics and the identification of the effect of a BCRP polymorphism in the Japanese population.
Pharmacogenet Genomics
; 27(1): 27-38, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27787353
13.
Delineating the Role of Various Factors in Renal Disposition of Digoxin through Application of Physiologically Based Kidney Model to Renal Impairment Populations.
J Pharmacol Exp Ther
; 360(3): 484-495, 2017 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28057840
14.
Microsomal and Cytosolic Scaling Factors in Dog and Human Kidney Cortex and Application for In Vitro-In Vivo Extrapolation of Renal Metabolic Clearance.
Drug Metab Dispos
; 45(5): 556-568, 2017 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-28270564
15.
In Vitro and in Silico Tools To Assess Extent of Cellular Uptake and Lysosomal Sequestration of Respiratory Drugs in Human Alveolar Macrophages.
Mol Pharm
; 14(4): 1033-1046, 2017 04 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-28252969
16.
Optimization of intestinal microsomal preparation in the rat: A systematic approach to assess the influence of various methodologies on metabolic activity and scaling factors.
Biopharm Drug Dispos
; 38(3): 187-208, 2017 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-28207929
17.
Meta-analysis of expression of hepatic organic anion-transporting polypeptide (OATP) transporters in cellular systems relative to human liver tissue.
Drug Metab Dispos
; 43(4): 424-32, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25564656
18.
Breast cancer resistance protein (ABCG2) in clinical pharmacokinetics and drug interactions: practical recommendations for clinical victim and perpetrator drug-drug interaction study design.
Drug Metab Dispos
; 43(4): 490-509, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25587128
19.
In Vitro Assessment of Uptake and Lysosomal Sequestration of Respiratory Drugs in Alveolar Macrophage Cell Line NR8383.
Pharm Res
; 32(12): 3937-51, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26224396
20.
Development and Application of a Mechanistic Pharmacokinetic Model for Simvastatin and its Active Metabolite Simvastatin Acid Using an Integrated Population PBPK Approach.
Pharm Res
; 32(6): 1864-83, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25446771